covid.datahelps.life

Wuhan Data

NB: this is version 1 (subset) of Wuhan01 cohort

775 COVID-19 positive patients from Wuhan, China. Most patients were under relatively mild conditions. The analytics below show the baseline and univariate analytics of the cohort.

Characteristics of Wuhan Cohort

Data are median (IQR) or number (%). Two patients had missing data for death, three patients had missing data for poor outcome.

Variable N (all) All (n=775)
Demographic    
Age 775 61 (50-68)
Sex (male) 775 379 (48.9%)
Outcome    
Death 773 33 (4.3%)
Poor outcome 772 75 (9.7%)
Underlying Conditions    
Chronic lung disease 771 48 (6.2%)
Diabetes Mellitus 771 106 (13.7%)
Weakened immune system 771 12 (1.5%)
Malignancy 771 24 (3.1%)
Hypertension 771 239 (30.8%)
Heart disease 771 85 (11.0%)
Chronic renal disease 771 25 (3.2%)
Symptoms    
fever 773 532 (68.6%)
coughing 773 528 (68.1%)
fatigue 773 421 (54.3%)
dyspnea 773 355 (45.8%)
diarrhea 773 36 (4.6%)
Admission clinical features    
CURB-65 Score 767 0 (0-1)
ARDS mild 764 1 (0.1%)
ARDS moderate 764 15 (1.9%)
ARDS severe 764 27 (3.5%)
IgM antibodies (g/L) 496 35.6 (12.6-77.0)
IgG antibodies (g/L) 498 153.3 (90.2-183.6)
Neutrophil count (10^9/L) 739 3.5 (2.7-4.9)
Lymphocyte (10^9/L) 743 1.4 (1.1-1.9)
Platelet (10^9/L) 732 224 (180-274)
C-reactive protein (mg/L) 684 2.7 (0.9-14.1)
D-dimer (mg/L) 581 0.4 (0.2-1.1)
Creatinine (μmol/L) 728 63.9 (54.1-76.4)
Alanine aminotransferase (IU/L) 723 22.9 (14.8-39.5)
Hospital course    
Hospitalisation duration 771 12 (8-20)
Interventions    
Oxygen therapy 772 576 (74.3%)
Noninvasive positive pressure ventilation 772 40 (5.2%)
High Flow Nasal Cannula 772 50 (6.5%)
Intubation 772 21 (2.7%)
Extracorporeal membrane oxygenation 772 2 (0.3%)
Steroid 772 78 (10.1%)

Univariate analytics of risk factors

Two patients had missing data for death, three patients had missing data for poor outcome. * For continuous variables, OR is per unit increase in value so should be interpreted in relation to the actual range of values (eg OR for a 60 year old vs a 30 year old is 1.06^30 = 5.74)


Variable
Death
Odds ratio (CI at 95%)

p-value
Poor outcome
Odds ratio (CI at 95%)

p-value
Demographic        
Age 1.06 (1.03-1.10) <0.0001 1.07 (1.04-1.09) <0.0001
Sex (male) 1.88 (0.91-3.87) 0.12 1.54 (0.95-2.50) 0.099
Premorbid Conditions        
Chronic lung disease 5.32 (2.15-13.13) 0.00029 6.13 (3.16-11.88) <0.0001
Diabetes Mellitus 2.38 (1.03-5.49) 0.069 1.58 (0.85-2.96) 0.2
Weakened immune system 5.21 (1.09-24.89) 0.12 7.35 (2.27-23.78) 0.00075
Malignancy 2.33 (0.52-10.39) 0.55 1.99 (0.66-5.99) 0.37
Hypertension 2.68 (1.29-5.58) 0.012 3.37 (2.06-5.53) <0.0001
Heart disease 4.43 (2.00-9.81) 0.00024 4.42 (2.51-7.77) <0.0001
Chronic renal disease 5.26 (1.68-16.42) 0.008 4.99 (2.07-12.02) 0.00032
Symptoms        
fever 1.16 (0.53-2.55) 0.86 1.08 (0.64-1.82) 0.88
coughing 3.35 (1.16-9.65) 0.03 1.49 (0.85-2.59) 0.2
fatigue 1.42 (0.68-2.95) 0.44 1.52 (0.93-2.50) 0.12
dyspnea 5.43 (2.21-13.35) <0.0001 3.33 (1.97-5.64) <0.0001
diarrhea 0.65 (0.09-4.89) 1 0.26 (0.03-1.92) 0.26
Admission clinical features        
Neutrophil count (10^9/L) 1.08 (1.02-1.14) 0.00034 1.33 (1.22-1.44) 0.0006
Lymphocyte (10^9/L) 0.02 (0.01-0.08) 0.002 0.17 (0.10-0.29) 0.0013
Platelet (10^9/L) 0.99 (0.98-1.00) 0.04 0.99 (0.99-1.00) 0.024
C-reactive protein (mg/L) 1.03 (1.02-1.04) <0.0001 1.03 (1.02-1.03) <0.0001
Creatinine (μmol/L) 1.01 (1.00-1.01) 0.0032 1.01 (1.01-1.02) 0.0093